Blar i Bergen Open Research Archive på forfatter "Henjum, Helge"

Viser treff 1-7 av 7

    • Combined RBE and OER optimization in proton therapy with FLUKA based on EF5-PET 

      Henjum, Helge; Dahle, Tordis Johnsen; Mairani, Andrea; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Boer, Camilla Grindeland; Redalen, Kathrine Røe; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)
      Introduction Tumor hypoxia is associated with poor treatment outcome. Hypoxic regions are more radioresistant than well-oxygenated regions, as quantified by the oxygen enhancement ratio (OER). In optimization of proton ...

    • The FLUKA Monte Carlo code coupled with an OER model for biologically weighted dose calculations in proton therapy of hypoxic tumors 

      Dahle, Tordis Johnsen; Rusten, Espen; Stokkevåg, Camilla Hanquist; Silvoniemi, Antti; Mairani, Andrea; Fjæra, Lars Fredrik; Rørvik, Eivind; Henjum, Helge; Wright, Pauliina; Boer, Camilla Grindeland; Forsback, Sarita; Minn, Heikki; Malinen, Eirik; Ytre-Hauge, Kristian (Journal article; Peer reviewed, 2020)
      Introduction The increased radioresistance of hypoxic cells compared to well-oxygenated cells is quantified by the oxygen enhancement ratio (OER). In this study we created a FLUKA Monte Carlo based tool for inclusion of ...

    • Hypoxia adapted relative biological effectiveness models for proton therapy: a simulation study 

      Garrido Hernandez, Guillermo; Henjum, Helge; Høiskar, Marte Kåstad; Dahle, Tordis Johnsen; Redalen, Kathrine; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2022)
      In proton therapy, a constant relative biological effectiveness (RBE) factor of 1.1 is applied although the RBE has been shown to depend on factors including the Linear Energy Transfer (LET). The biological effectiveness ...

    • Influence of beam pruning techniques on LET and RBE in proton arc therapy 

      Henjum, Helge; Tjelta, Johannes; Fjæra, Lars Fredrik; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla Hanquist; Lyngholm, Erlend; Handeland, Andreas Havsgård; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2023)
      Introduction: Proton arc therapy (PAT) is an emerging treatment modality that holds promise to improve target volume coverage and reduce linear energy transfer (LET) in organs at risk. We aimed to investigate if pruning ...

    • Optimization of proton therapy plans with respect to biological and physical dose distributions 

      Henjum, Helge (Master thesis, 2018-06-16)
      Introduction: Proton therapy is a radiation treatment method growing around the world. This is mainly due to the protons ability to deposit dose more conformal compared to conventional photon therapy. Protons also differ ...

    • The Organ Sparing Potential of Different Biological Optimization Strategies in Proton Therapy 

      Henjum, Helge; Dahle, Tordis Johnsen; Fjæra, Lars Fredrik; Rørvik, Eivind; Pilskog, Sara Margareta Cecilia; Stokkevåg, Camilla H.; Mairani, Andrea; Ytre-Hauge, Kristian Smeland (Journal article; Peer reviewed, 2021)
      Purpose: Variable relative biological effectiveness (RBE) models allow for differences in linear energy transfer (LET), physical dose, and tissue type to be accounted for when quantifying and optimizing the biological ...

    • Treatment planning optimization strategies for the relative biological effectiveness and oxygen enhancement ratio in proton therapy 

      Henjum, Helge (Doctoral thesis, 2022-09-23)
      Sidan kreftbehandling med proton gir ein høgare biologisk effekt enn foton, blir ein relativ biologisk effekt (RBE) brukt for å ta omsyn til forskjellen. I klinisk protonterapi i dag blir ein konstant RBE på 1.1 nytta, ...